Researchers at the Institut de Neurociències of the Universitat Autònoma de Barcelona have developed a mussel‑inspired bioadhesive patch designed to eliminate glioblastoma cells, the most aggressive and prevalent form of brain tumor. The patch adheres strongly to wet brain tissue and induces a high level of localized cellular oxidation, allowing it to kill tumor cells while minimizing systemic side effects. The approach has been tested in cell cultures and in excised pig brains, where it demonstrated the ability to eliminate a large proportion of glioblastoma cells.
Glioblastoma grows rapidly, infiltrates surrounding tissue, and is extremely difficult to treat. Standard care involves surgical removal followed by radiotherapy and chemotherapy, yet recurrence is common within a year and no existing treatment can halt disease progression. The new patch offers a localized therapeutic strategy that does not rely on systemic drug delivery, potentially reducing toxicity and improving precision.
Article from UAB: A bioadhesive patch inspired by mussel adhesion eliminates cells from the most aggressive brain tumor
Abstract in Advanced Science: A Mussel-Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells
