La Trobe University researchers have developed an ultra sensitive single use test strip that can detect microRNAs at extremely low concentrations, offering a simpler and more accessible method for early disease diagnosis.
MicroRNAs are important biomarkers for conditions such as cancer, but they are difficult to measure because they appear in very small amounts. The new strip uses an enzymatic amplification process that strengthens the electrical signal produced when microRNAs bind to the sensor, allowing detection at levels far below what standard laboratory techniques can measure. The device works like a glucose test strip and does not require specialized equipment, making it suitable for point of need testing in clinics or remote settings.
The team believes this technology could support earlier diagnosis and broaden access to molecular testing by reducing dependence on complex laboratory infrastructure.
Article from La Trobe University: Test strip breakthrough for accessible diagnosis
Abstract in Small: Duplex-Specific DNase Signal Amplification Allows Attomolar Electrochemical Detection of MicroRNAs
