Researchers at Pohang University of Science and Technology (POSTECH) in Korea have created a bioadhesive sponge that can rapidly stop internal bleeding, especially in high-risk surgeries involving organs like the liver or spleen. The sponge combines mussel adhesive protein with decellularized extracellular matrix (dECM) to provide strong tissue adhesion and support wound healing.
Traditional hemostatic agents often fail to stick to wet tissue or degrade properly, leading to complications. The POSTECH sponge addresses these issues by adhering firmly to bleeding sites and activating the body’s natural clotting mechanisms. Once bleeding is controlled, the sponge biodegrades safely, while the dECM promotes tissue recovery.
In tests using anticoagulated liver injury models, the sponge significantly reduced bleeding time and blood loss. It also caused less inflammation and tissue damage compared to conventional materials. The researchers believe this technology could reduce the need for follow-up surgeries and improve outcomes in trauma care.
The study was led by Professors Hyung Joon Cha and Jinah Jang and published in Advanced Healthcare Materials. The team plans to explore broader applications for the sponge in emergency medicine and surgical procedures.
Article from POSTECH: A Bioadhesive Sponge Inspired by Mussels and Extracellular Matrix Offers a New Way to Stop Internal Bleeding
Abstract in Advanced Healthcare Materials: Absorbable Adhesive Composite Hemostatic Sponge Based on Decellularized Extracellular Matrix and Mussel Adhesive Protein for Internal Bleeding Control
