Inspired by the microscopic gripping power of gecko toes, researchers at the University of Colorado Boulder and CU Anschutz have developed a new cancer therapy that adheres tightly to tumors and delivers chemotherapy drugs over several days. The innovation centers on “soft dendritic particles” (SDPs)—biodegradable nanoparticles engineered to mimic the branched, hair-like structures found on gecko feet. These nanostructures exploit Van der Waals forces to stick to slippery surfaces, much like geckos climbing glass.
The team used an FDA-approved polymer, poly lactic-co-glycolic acid (PLGA), to fabricate the particles, then infused them with chemotherapy drugs. When applied to bladder tumors in mice, the particles clung to the cancerous tissue for days, even in the constantly flushing environment of the bladder. This prolonged contact allowed for sustained drug release and triggered a favorable immune response, with minimal toxicity to surrounding healthy tissue.
Bladder cancer was chosen as the initial target due to its treatment challenges. Current therapies involve bathing the bladder in chemotherapy via catheter, but frequent urination quickly washes the drugs away, requiring repeated and often painful treatments. The gecko-inspired particles could be embedded in a gel and applied directly to the tumor, offering a more targeted and long-lasting alternative.
Article from CU Boulder: New cancer therapy clings to tumors, with inspiration from gecko toes
Abstract in Advanced Materials: Soft Extrudable Dendritic Particles with Nanostructured Tendrils for Local Adhesion and Drug Release to Bladder Cancers
